METHODS, COMPOSITIONS, AND COMPOUNDS FOR ALLOSTERIC MODULATION OF THE GABA RECEPTOR BY MEMBERS OF THE ANDROSTANE AND PREGNANE SERIES

Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified si te on the gamma-aminobutyric acid receptor-chloride ion-ophore (GR) complex.

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Bibliographische Detailangaben
Hauptverfasser: BELELLI, DELIA, TAHIR, SYED H, PURDY, ROBERT H, BOLGER, MICHAEL B, LAN, NANCY T, UPASANI, RAVINDRA B, GEE, KELVIN W, MIRSADEGHI, SEID
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified si te on the gamma-aminobutyric acid receptor-chloride ion-ophore (GR) complex.