17-SPIROFURAN-3'-YLIDENE STEROIDS

17-SPIROFURAN-3'-YLIDENE STEROIDS

The invention relates to an antiprogestin 17-spirofuran- 3'-ylidene steroid having the formula wherein R1 is NR2R3, lower acyl, OH, SH, O-lower alkyl or S(O)n- lower alkyl wherein n is 0-2; R2 and R3 are independently selected from hydrogen and lower alkyl; R4 is hydrogen or lower alkyl; R5 is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: REWINKEL, JOHANNES BERNARDUS MARIA, HAMERSMA, JOHANNES A. M, ORLEMANS, EVERARDUS O. M
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Beschreibung
Zusammenfassung:The invention relates to an antiprogestin 17-spirofuran- 3'-ylidene steroid having the formula wherein R1 is NR2R3, lower acyl, OH, SH, O-lower alkyl or S(O)n- lower alkyl wherein n is 0-2; R2 and R3 are independently selected from hydrogen and lower alkyl; R4 is hydrogen or lower alkyl; R5 is O, (H, H), (H,OH), (H,O-lower acyl), or NOH; R6 and R7 are both hydrogen, or one is hydrogen and the other lower alkyl: and the twitched line represents an .alpha. or .beta. bond.