PROCESS FOR PREPARING DOUBLY BLOCKED 1-CARBA(1-DETHIA)-3-CEPHEM-4-CARBOXYLIC ACIDS

PROCESS FOR PREPARING DOUBLY BLOCKED 1-CARBA(1-DETHIA)-3-CEPHEM-4-CARBOXYLIC ACIDS

X-8142 A process is provided for producing 7-protected-amino-4-protected carboxy-3-halo-1-carbacephalosporins which includes the steps of mixing the hydrochloride salt of the carbacephalosporin with a polar organic aprotic solvent having a dielectric constant of at least about 20 and a base selected...

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Bibliographische Detailangaben
1. Verfasser: BERGLUND, RICHARD A
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:X-8142 A process is provided for producing 7-protected-amino-4-protected carboxy-3-halo-1-carbacephalosporins which includes the steps of mixing the hydrochloride salt of the carbacephalosporin with a polar organic aprotic solvent having a dielectric constant of at least about 20 and a base selected from a group consisting of 5- or 6membered tertiary cyclic amine containing 0-1 oxygen atoms, and dimethylbenzamine to form the free amine of a carbacephalosporin and thereafter without isolating the free amine mixing it with an acylating agent to result in the doubly blocked carbacephalosporin.