QUINOLONE CARBOXYLIC ACID DERIVATIVES

QUINOLONE CARBOXYLIC ACID DERIVATIVES

A quinolone carboxylic acid derivative having the following formula (1), (See formula I) wherein R1 is a hydrogen atom, an alkyl group, an aralkyl group, or an ester residual group which can be hydrolyzed in living bodies, R2 is a hydrogen atom or an amino group which may be substituted by one or tw...

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Hauptverfasser: ASAOKA, TAKEMITSU, KAWAHARA, RYUICHI, KONNO, FUJIKO, SHIBATA, AKIHIRO, TAKEDA, SUNAO, TAIDO, NAOKATA, MATSUDA, HIDEAKI, KURAISHI, TADAYUKI
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A quinolone carboxylic acid derivative having the following formula (1), (See formula I) wherein R1 is a hydrogen atom, an alkyl group, an aralkyl group, or an ester residual group which can be hydrolyzed in living bodies, R2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH2, O, S, SO, SO2, or N-R3, wherein R3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; or a salt thereof; and an antimicrobial agent comprising the same. The compound exhibits a superior antimicrobial activity, especially against gram positive microorganisms, and is thus useful for the treatment and prevention of various infectious diseases in clinics.