CDR GRAFTED ANTI-CEA ANTIBODIES AND THEIR PRODUCTION

The present invention provides humanised antibody molecules (HAMs) having specificity for carcinoembryonic antigen CEA) and having an antigen binding site wherein at least one of the complementarily determining regions (CDRs) of the var- iable domains is derived from the mouse monoclonal antibody A5...

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Bibliographische Detailangaben
Hauptverfasser:	BODMER, MARK W, OWENS, RAYMOND J, MOUNTAIN, ANDREW, ADAIR, JOHN R
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides humanised antibody molecules (HAMs) having specificity for carcinoembryonic antigen CEA) and having an antigen binding site wherein at least one of the complementarily determining regions (CDRs) of the var- iable domains is derived from the mouse monoclonal antibody A5B7 ( B7 MAb) and the remaining immunoglobulin-derived parts of the HAM are derived from a human immunoglobulin. The HA may be chimeric humanised antibodies or CDR-graft- ed humanised antibodies and are preferably produced by recombinant DNA techniques. The HAMs are useful for in vivo diag- nosis and therapy. 2065325 9201059 PCTABS00010 The present invention provides humanised antibody molecules (HAMs) having specificity for carcinoembryonic antigen (CEA) and having an antigen binding site wherein at least one of the complementarity determining regions (CDRs) of the variable domains is derived from the mouse monoclonal antibody A5B7 (A5B7 MAb) and the remaining immunoglobulin-derived parts of the HAM are derived fron a human immunoglobulin. The HAMs may be chimeric humanised antibodies or CDR-grafted humanised antibodies and are preferably produced by recombinant DNA techniques. The HAMs are useful for in vivo) diagnosis and therapy.