A PHYSICAL FORM OF N-[4-[5-(CYCLOPENTYLOXYCARBONY)AMINO-1-METHYLINDOL-3YL-METHY1]-3-METHOXYBENZOY1]-2-METHLBENZENESULPHONAMIDE, PROCESSES FOR ITS PREPARATION AND COMPOSITIONS CONTAINING IT

A PHYSICAL FORM OF N-[4-[5-(CYCLOPENTYLOXYCARBONY)AMINO-1-METHYLINDOL-3YL-METHY1]-3-METHOXYBENZOY1]-2-METHLBENZENESULPHONAMIDE, PROCESSES FOR ITS PREPARATION AND COMPOSITIONS CONTAINING IT

The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxy- carbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxybenzoyl]-2-methyl- benzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and ano...

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Bibliographische Detailangaben
Hauptverfasser: TIMKO, ROBERT J, HOLOHAN, JAMES J, CLEMENTS, ARLENE, BRADWAY, RANDY J, EDWARDS, IEUAN J
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxy- carbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxybenzoyl]-2-methyl- benzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and another physical form of N-[4-[S-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]- -3-methoxybenzoyl]-2-methylbenzenesulphonamide useful in the preparation of the first mentioned physical form. The compositions are useful in the treatment of diseases in which leukotrienes are implicated, for example asthma.