DIKETENE IMINE DERIVATIVE AND PROCESS FOR PREPARING SAME

DIKETENE IMINE DERIVATIVE AND PROCESS FOR PREPARING SAME

The invention relatss to the novel compound of formula (I), (I) chemically 1-{2-¢(5-N,N-dimethylaminomethyl-2-furyl)-methylthio!ethyl}-2-{2-¢(5-N,N-dimethylaminomethyl-2-furyl)-methylthio!-1-ethylamino}-3-nitro-4-nitromethylene- -2-azetine, which is a useful key intermediate in the synthesis of 1-{2...

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Hauptverfasser: KALVIN, PETER, MEGYERI, GABOR, GODO, LASZLO, HERMANN, LASZLO, LOSONCZI, BELA, JESZENSZKI, ANDOR, HAVASI, GABOR, BENCZIK, TAMAS, STEFKO, BELA, STEFAN, LASZLO, CZEH, MARIA
Format: Patent
Sprache:eng ; fre
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APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator KALVIN, PETER
MEGYERI, GABOR
GODO, LASZLO
HERMANN, LASZLO
LOSONCZI, BELA
JESZENSZKI, ANDOR
HAVASI, GABOR
BENCZIK, TAMAS
STEFKO, BELA
STEFAN, LASZLO
CZEH, MARIA
description The invention relatss to the novel compound of formula (I), (I) chemically 1-{2-¢(5-N,N-dimethylaminomethyl-2-furyl)-methylthio!ethyl}-2-{2-¢(5-N,N-dimethylaminomethyl-2-furyl)-methylthio!-1-ethylamino}-3-nitro-4-nitromethylene- -2-azetine, which is a useful key intermediate in the synthesis of 1-{2-¢(5-dimethylaminomethyl-2-furyl)methyl-thio!ethyl}-amino-1-methylamino-2-nitroethylene (generic name: ranitidine), a known H-2 receptor antagonist. The invention further relates to a process for the preparation of the compound of formula (I), which can be carried out in one simple process step on industrial scale, too. The compound of formula (I) can easily be transformed to ranitidine in one simple step.
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The invention further relates to a process for the preparation of the compound of formula (I), which can be carried out in one simple process step on industrial scale, too. 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subjects APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title DIKETENE IMINE DERIVATIVE AND PROCESS FOR PREPARING SAME
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