DIKETENE IMINE DERIVATIVE AND PROCESS FOR PREPARING SAME

DIKETENE IMINE DERIVATIVE AND PROCESS FOR PREPARING SAME

The invention relatss to the novel compound of formula (I), (I) chemically 1-{2-¢(5-N,N-dimethylaminomethyl-2-furyl)-methylthio!ethyl}-2-{2-¢(5-N,N-dimethylaminomethyl-2-furyl)-methylthio!-1-ethylamino}-3-nitro-4-nitromethylene- -2-azetine, which is a useful key intermediate in the synthesis of 1-{2...

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Bibliographische Detailangaben
Hauptverfasser: KALVIN, PETER, MEGYERI, GABOR, GODO, LASZLO, HERMANN, LASZLO, LOSONCZI, BELA, JESZENSZKI, ANDOR, HAVASI, GABOR, BENCZIK, TAMAS, STEFKO, BELA, STEFAN, LASZLO, CZEH, MARIA
Format: Patent
Sprache:eng ; fre
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relatss to the novel compound of formula (I), (I) chemically 1-{2-¢(5-N,N-dimethylaminomethyl-2-furyl)-methylthio!ethyl}-2-{2-¢(5-N,N-dimethylaminomethyl-2-furyl)-methylthio!-1-ethylamino}-3-nitro-4-nitromethylene- -2-azetine, which is a useful key intermediate in the synthesis of 1-{2-¢(5-dimethylaminomethyl-2-furyl)methyl-thio!ethyl}-amino-1-methylamino-2-nitroethylene (generic name: ranitidine), a known H-2 receptor antagonist. The invention further relates to a process for the preparation of the compound of formula (I), which can be carried out in one simple process step on industrial scale, too. The compound of formula (I) can easily be transformed to ranitidine in one simple step.