BIOSYNTHETIC PRODUCTION OF 6(R)-[2-(8(S)-HYDROXY-2(S), 6(R)-DIMETHYL-1,2,6,7,8,8A(R)-HEXAHYDRONAPHTHYL)-ETHYL]-4 (R)-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONE TRIOL ACID BY ENZYMATIC HYDROLYSIS OF LOVASTATIN ACIDUSING AN ENZYME DERIVED FROM__LONOSTACHYS COMPACTIUSCULA

Biosynthetic production of 6(R)-¢2-(8(S)-hydroxy-2(S),6(R)-dimethyl-1,2,6,7,8,8a- (R)-hexahydronaphthyl)ethyl!-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one triol acid is obtained by enzymatic hydrolysis of lovastatin acid or a salt thereof, by treating it with Clonostachys compactiuscula or mutant...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	CONDER, MICHAEL J, STIEBER, ROBERT W, COVER, WILLIAM H, DABORA, REBECCA L, TEHLEWITZ, BOGDAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Biosynthetic production of 6(R)-¢2-(8(S)-hydroxy-2(S),6(R)-dimethyl-1,2,6,7,8,8a- (R)-hexahydronaphthyl)ethyl!-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one triol acid is obtained by enzymatic hydrolysis of lovastatin acid or a salt thereof, by treating it with Clonostachys compactiuscula or mutants thereof, or a hydrolase derived therefrom. The triol acid may be converted in a straightforward manner to its lactone form; and both are inhibitors of HMG-CoA reductase and thus useful as antihypercholesterolemic agents, and may also serve as intermediates for preparation of other HMG-CoA reductase inhibitors.