LFA-3 AS A VACCINE ADJUVANT

LFA-3 AS A VACCINE ADJUVANT

2049931 9111194 PCTABS00006 Vaccines comprising an immunogen and, as an adjuvant, LFA-3 or a fragment of LFA-3 capable of binding to CD2, a surface receptor on T-lymphocytes, are disclosed. LFA-3 has been found to markedly enhance the proliferation of activated T-cells and thus is capable of augment...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CRIMMINS, MARY A. V, THOMAS, DAVID W, BENJAMIN, CHRISTOPHER D, WALLNER, BARBARA P
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:2049931 9111194 PCTABS00006 Vaccines comprising an immunogen and, as an adjuvant, LFA-3 or a fragment of LFA-3 capable of binding to CD2, a surface receptor on T-lymphocytes, are disclosed. LFA-3 has been found to markedly enhance the proliferation of activated T-cells and thus is capable of augmenting the immune response. Methods of vaccination in which LFA-3 is employed in conjunction with an immunogenic inoculum are also disclosed.