PROCESS FOR IODINATING OR BROMINATING THE ALPHA-METHYLENIC CARBON OF A SECONDARY AMIDE

PROCESS FOR IODINATING OR BROMINATING THE ALPHA-METHYLENIC CARBON OF A SECONDARY AMIDE

A novel, facile, and specific process for .alpha.-iodinating or .alpha. - brominating the .alpha.-methylenic carbon of an azasteroid, comprises reacti ng the amide with trialkylsilyl-X (R3Si-X), where X is Br, I, or Cl, and R is methy l, ethyl, or n-propyl, in the presence of I2 or Br2. The .alpha.-...

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Bibliographische Detailangaben
Hauptverfasser: KARADY, SANDOR, ANDERSON, KEVIN, SHUMAN, RICHARD F, ABRAMSON, NEWTON L, KING, ANTHONY O
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
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Beschreibung
Zusammenfassung:A novel, facile, and specific process for .alpha.-iodinating or .alpha. - brominating the .alpha.-methylenic carbon of an azasteroid, comprises reacti ng the amide with trialkylsilyl-X (R3Si-X), where X is Br, I, or Cl, and R is methy l, ethyl, or n-propyl, in the presence of I2 or Br2. The .alpha.-iodo- or .alph a.- bromo-amide is useful for making the .alpha.,.beta.-unsaturated amide through dehydrohalogenation.