ANTIMICROBIAL PEPTIDES ACTIVE AGAINST PLANT PATHOGENS, THEIRMETHOD OF USE AND VARIOUS SCREENING METHODS PERTAINING THERETO

The invention relate to a composition of matter comprising either a peptide having the amino acid sequence Gly- Ile-Gly-Lys-Phe-Xaa-Xaa-Xaa-Ala-Xaa-Xaa-Phe-Xaa-Lys-Ala- Phe-Val-Xaa-Xaa-Ile-Xaa-Lys-Xaa wherein Xaa6, Xaa7, Xaa8, Xaa11, Xaa13, Xaa18, Xaa19, Xaa21 and Xaa23, may be the same or different...

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Bibliographische Detailangaben
Hauptverfasser:	BASCOMB, NEWELL F, WILLIAMS, JON I, MAPELLI, CLAUDIO, SWERDLOFF, MICHAEL D, EVERETT, NICHOLAS P
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PEST REPELLANTS OR ATTRACTANTS PHYSICS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relate to a composition of matter comprising either a peptide having the amino acid sequence Gly- Ile-Gly-Lys-Phe-Xaa-Xaa-Xaa-Ala-Xaa-Xaa-Phe-Xaa-Lys-Ala- Phe-Val-Xaa-Xaa-Ile-Xaa-Lys-Xaa wherein Xaa6, Xaa7, Xaa8, Xaa11, Xaa13, Xaa18, Xaa19, Xaa21 and Xaa23, may be the same or different and are selected from the group consisting of Ala, Arg, Orn, Asn, Asp, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, 3Hyp, 4Hyp, Ser, Thr, Trp, Tyr, 3,4- dihydroxyphenylalanine and Val, and wherein Xaa10 is selected from the group consisting of Ala, Arg, Orn, Asn, Asp, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Ser, Thr, Trp, Tyr, 3,4-dihydroxyphenylalanine, and Val, with the proviso that said peptide is not Magainin 1; or a peptide having the amino acid sequence Gly-Ile-Gly-Lys-Phe-Xaa-Xaa-Xaa-Ala-Xaa-Xaa-Phe-Xaa-Lys- Ala-Phe-Val-Xaa-Xaa-Ile-Xaa-Asn-Xaa wherein Xaa6, Xaa7, Xaa8, Xaa11, Xaa13, Xaa18, Xaa19, Xaa21 and Xaa23 may be the same or different and are selected from the group consisting of Ala, Arg, Orn, Asn, Asp, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, 3Hyp, 4Hyp, Ser, Thr, Trp, Tyr, 3,4- dihydroxyphenylalanine and Val, and wherein Xaa10 is selected from the group consisting of Ala, Arg, Orn, Asn, Asp, Gln, Glu, Gly,His, Ile, Leu, Lys, Met, Phe, Ser, Thr, Trp, Tyr, 3,4-dihydroxyphenylalanine and Val with the proviso that said peptide is not Magainin 2, Magainin 2 substituted only at Xaa21, Magainin 2 substituted only in at least two of Xaa8, Xaa13 and Xaa18 with Ala and with the further proviso that said peptide is not Magainin 2 substituted with only a single Ala, in association with an acceptable carrier. The present invention relates to the field of peptides which are useful for combating plant pathogens, and methods of their use against plant pathogens. The present inven- tion also relates to screening methods useful in conjunc- tion therewith.