ETOPOSIDE ANALOGUES

Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have the following formula: where: R1 is .beta.-OCH2CH2NH2 .beta.-NHCH(CH3)CH2OH, .beta.NHCH2CH(CH3)OH, .beta.-Cl, .beta.-Br, .beta.-OH, .alpha.-OH, .beta.-NH2, .alpha.-NH2, ....

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Bibliographische Detailangaben
Hauptverfasser:	LEE, KUO-HSIUNG, BEERS, SCOTT A, IMAKURA, YASUHIRO, LIU, SU-YING, KUO, YAO H, DAI, HUA-JUAN, HARUNA, MITSUMASA, THURSTON, LEE S, SCHNUR, DORA M, CHEN, CHUNG-HSIUNG, WANG, ZHE Q, BOWEN, J. PHILLIP, MORI, MASAMI, CHENG, YUNGI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have the following formula: where: R1 is .beta.-OCH2CH2NH2 .beta.-NHCH(CH3)CH2OH, .beta.NHCH2CH(CH3)OH, .beta.-Cl, .beta.-Br, .beta.-OH, .alpha.-OH, .beta.-NH2, .alpha.-NH2, .beta.-NHCH2CH2OH, .alpha.-NHCH2CH2OH, .beta.-NHCH2CH2CH3, .beta.NHCH2CH2OCH3, .beta.-NHCH2CH=CH2, .beta.-NHCH2CH(OH)CH3, .beta.NHCH2CH2CH2OH, .beta.-OCH2CH2OH, , , , , , , , , , , , , , , , , , , , , , or . R2 is H, or Br; R3 is H, or Br; R4 is H, or Br; R5 is H, or Br; and R6 is H, or -CH3.