C-LINKED PYRAZOLE DERIVATIVES

C-LINKED PYRAZOLE DERIVATIVES The invention provides compounds of the general formula (I): (I) or a physiologically acceptable salt, solvate (e.g. hydrate) or a metabolically labile ester thereof in which R1 represents a hydrogen atom or a group selected from C1-6alkyl or C2-6alkenyl; R2 represents a hydrogen atom or a group selected from C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, C3-6alkenyl, fluoroC1-6alkyl, fluoroC3-6alkenyl, phenyl, -(CH2)kCOR5 or -(CH2)kSO2R5; R3 represents a hydrogen atom or a group selected from C1-6alkyl optionally substituted by a hydroxy or C1-6alkoxy group, C2-6alkenyl, fluoroC1-6alkyl, -(CH2)mR6, -(CH2)nCOR7 or -(CH2)pNR8COR9; R4 represents a group selected from -CO2H, -NHSO2CF3 or a C-linked tetrazolyl group; R5 represents a group selected from C1-6alkyl, C2-6alkenyl, C1-6alkoxy or the group -NR10R11; R6 represents a phenoxy or benzyloxy group; R7 represents a hydrogen atom or a group selected from hydroxy, 1-6alkyl, C1-6alkoxy, phenyl, phenoxy or the group -NR10Rl1; R8 represents a hydrogen atom or a C1-6alkyl group; R9 represents a hydrogen atom or a group selected from C1-6alkyl, C1-6alkoxy, phenyl, benzyl, phenoxy or the group -NR10R11; R10 and R11 which may be the same or different each independently represent a hydrogen atom or a C1-4alkyl group or -NR10R11 forms a saturated heterocyclic ring which has 5 or 6 ring members and may optionally contain in the ring one oxygen atom; CV306/Abs. X represents zero or an integer from 1 to 4; m represents an integer from 1 to 4: n represents zero or an integer from 1 to 4; and p represents an integer from 1 to 4. The compounds may be used in the treatment or prophylaxis of hypertension and diseases associated with cognitive disorders. CV306/Abs.