BENZISOTHIAZOLINONE-1-DIOXIDE DERIVATIVES AS ELASTASE INHIBITORS

ABSTRACT BENZISOTHIAZOLINONE-1-DIOXIDE DERIVATIVES AS ELASTASE INHIBITORS The invention relates to pharmaceutical and cosmetic compositions comprising at least one benzisothiazolinone-1-dioxide derivative with the formula: (1) where R1 can be hydrogen, and R2 can be certain generally hydrophobic C8-C20 aliphatic groups or the group: (III) where R5 is aliphatic or else R2 is a saturated or unsaturated C2-C6 group ending in an aromatic nucleus. These compositions can be used to inhibit elastases such as human leucocytic elastase. They may be applied topically as a cosmetic. Many of the benzisothiazolinone-1-dioxide derivative specified as active ingredient in such compositions are novel compounds.