N-(4-PIPERIDINYL) (DIHYDROBENZOFURAN OR DIHYDRO-2H-BENZOPYRAN) CARBOXAMIDE DERIVATIVES

N-(4-PIPERIDINYL) (DIHYDROBENZOFURAN OR DIHYDRO-2H-BENZOPYRAN) CARBOXAMIDE DERIVATIVES

Piperidine derivatives of formula (SEE FORMULA) wherein A is a radical of formula -CH2-CH2- (a-1), -CH2-CH2-CH2- (a-2), or -CH2-CH2-CH2-CH2- (a-3), wherein one or two hydrogen atoms in said radicals (a-1) to (a-3) may be replaced by a C1-6alkyl radical; R1 is hydrogen or halo; R2 is hydrogen, amino,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BOSMANS, JEAN-PAUL R. M. A, VAN DAELE, GEORGES H. P, DE CLEYN, MICHEL A. J
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Piperidine derivatives of formula (SEE FORMULA) wherein A is a radical of formula -CH2-CH2- (a-1), -CH2-CH2-CH2- (a-2), or -CH2-CH2-CH2-CH2- (a-3), wherein one or two hydrogen atoms in said radicals (a-1) to (a-3) may be replaced by a C1-6alkyl radical; R1 is hydrogen or halo; R2 is hydrogen, amino, mono or di(C1-6alkyl)ami no or C1-6alkylcarbonylamino; R3 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C3-6alkenyl optionally substituted with aryl, or L is a radical of formula -Alk-R4 (b-1), -Alk-X-R5 (b-2), -Alk-Y-C(=O)-R7 (b-3), or -Alk-Y-C(=O)NR9R10 (b-4), the N-oxide foams, addition salts and stereochemically isomeric form thereof , said compounds having gastrointestinal motility stimulating properties pharmaceutical compositions containing these compounds as active ingredient, and a method o f preparing said compounds and pharmaceutical compositions.