BIS-(1H-INDOL-3-YL)-MALEINIMIDE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS

BIS-(1H-INDOL-3-YL)-MALEINIMIDE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS

The present invention provides bis-(1H-indol-3-yl)- maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: OSWALD, HARTMUT, RUDOLPH, CLAUS, SCHAECHTELE, CHRISTOPH, RECK, REINHARD, BETCHE, HANS-JURGEN, BARTH, HUBERT, HARTENSTEIN, JOHANNES
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides bis-(1H-indol-3-yl)- maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension of inflammatory processes, allergies, cancer and certain degenerative damages of the central nervous system, as well as of diseases of the immune system and viral diseases. The maleinimide derivatives of the invention are of formula I and an example is the compound in which R1 is methyl and R2, R4, R5, R8 and R9 are each hydrogen.