PROCESS FOR THE PREPARATION OF QUINAZOLINE DERIVATIVES

Procedure for preparation of quinazoline derivatives. The invention is related to a procedure for the preparation of quinazoline derivatives of general formula i, in which rbs1 and rbs2 can be equal or different and represent hydrogen or lower rent, or jointly form a group ethylene or trimethylene,...

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Bibliographische Detailangaben
Hauptverfasser:	SZTUHAR, ILONA, PONGO, LASZLO, GORGENYI, FRIGYES, CSORGO, MARGIT, FEKETE, MARTON, REITER, JOZEF
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	Procedure for preparation of quinazoline derivatives. The invention is related to a procedure for the preparation of quinazoline derivatives of general formula i, in which rbs1 and rbs2 can be equal or different and represent hydrogen or lower rent, or jointly form a group ethylene or trimethylene, yn is 2 or 3, characterized by the reaction of a 1,2 dimetoxy phenyl 4 istitiourea derivative, with a diamincarboxifuran derivative, eventually substituted, and posterior cyclation, thermal or catalytic, of the compound so obtained. The invention is also related, with the preparation of the intermediate reaction compounds. The compounds object of this invention have interesting properties pharmaceutical as antihypertensive and blockers of si1 receptors. (Machine-translation by Google Translate, not legally binding)