CERTAIN PYRROLYLPHENYL-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES

CERTAIN PYRROLYLPHENYL-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES Disclosed are the pyrrolylphenyl-substituted hydroxamic acid derivatives of the formula (I) wherein R represents hydrogen, lower alkyl, halogen or lower alkoxy; R1 and R2 indepen-dently represent hydrogen, lower alkyl or aryl; Y represents a direct bond, lower alkylene, lower alkenylene, lower alkadienylene, (thio, sulfinyl or sulfonyl)-lower alkylene or oxylower alkylene; Z represents (a) wherein R3 represents hydrogen or acyl; R4 represents lower alkyl, C3-C7-cycloalkyl, aryl or aryl-lower alkyl; or Z represents l (b) wherein R3 represents hydrogen or acyl; R5 represents lower alkyl, C3-C7-cycloalkyl, aryl, aryl-lower alkyl, amino or N-(mono- or di-lower alkyl)-amino; R6 and R7 represent hydrogen or lower alkyl; and pharmaceutically acceptable salts thereof provided that R3 represents hydrogen; which are useful as selective lipoxygenase inhibitors, methods for preparation thereof, pharmaceutical compositions comprising said compounds, and a method of inhibiting lipoxygenase and of treating diseases in mammals which are respon-sive to lipoxygenase inhibition using said compounds and pharmaceutical compositions comprising said compounds of the invention.