PHENANTHROLINEDICARBOXYLATE ESTERS, 4-AMINOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE

PHENANTHROLINEDICARBOXYLATE ESTERS, 4-AMINOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE

A method for treating a human patient afflicted with human immunodeficiency virus comprising administering to such patient an effective amount of a compound of formula IA IA wherein R, R1 and R2 are as defined in the specification, e.g., dimethyl 1,4,7,10-tetrahydro-4,10-dioxo-6-(n-pentyl)-1,7-phena...

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Bibliographische Detailangaben
Hauptverfasser: REUSSER, FRITZ, TARPLEY, WILLIAM G, SKALETZKY, LOUIS L, ALTHAUS, IRENE W
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A method for treating a human patient afflicted with human immunodeficiency virus comprising administering to such patient an effective amount of a compound of formula IA IA wherein R, R1 and R2 are as defined in the specification, e.g., dimethyl 1,4,7,10-tetrahydro-4,10-dioxo-6-(n-pentyl)-1,7-phenanthro-line-2,8-dicarboxylate; a compound of formula IB IB ,e.g., 1-benzoyl-4-¢¢7-(trifluoromethyl)-4-quinolinyl!amino!benzoyl-piperazine, and salts thereof such as the maleate salt are described; a compound of formula IC IC ,e.g., 4-¢(7-chloro-4-quinolyl)amino!-.alpha.-¢¢4-¢(6-methoxy-8-quinolyl)-amino!pentyl!amino!-.alpha.'-1-pyrrolidinyl-2,6-xylenol trihydrochloride , and a compound of Formula ID ID ,e.g., 2'-¢(5,5-dimethoxy-1-isoquinolyl)methyl!-4',5'-dimethoxyacetophenone.