PIPERIDINYL BENZIMIDAZOLES

PIPERIDINYL BENZIMIDAZOLES

The present invention is directed to a new class of piperidinyl benzimidazole derivatives of the formula: wherein Y is represented by CO or CHOH; m is an integer from 1 to 2; R is represented by C1-4 alkyl, C1-4 alkoxy, halogen, hydroxy and hydrogen; X is represented by hydrogen, COOR2 in which R2 i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KANE, JOHN MICHAEL, CHENG, HSIEN CHANG, CARR, ALBERT ANTHONY
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention is directed to a new class of piperidinyl benzimidazole derivatives of the formula: wherein Y is represented by CO or CHOH; m is an integer from 1 to 2; R is represented by C1-4 alkyl, C1-4 alkoxy, halogen, hydroxy and hydrogen; X is represented by hydrogen, COOR2 in which R2 is represented by a C1-4 alkyl, or X is an alkylene phenyl radical of the formula: wherein T is represented by CHOH, CO, O, or a direct bond; R1 is represented by C1-4 alkyl, C1-4 alkoxy, halogen, hydroxy, 2,2-dimethyl ethanoic acid and hydrogen; n is an integer from 1 to 5; and pharmaceutically acceptable acid addition salts thereof; which are useful as antihistamines.