MODIFICATIONS OF SOMATOTROPINS FOR ENHANCED STABILITY

The present invention discloses variant somatotropins in which the asparagine located between positions 95-101 of a mammalian somatotropin are replaced by glutamine. Such somatotropins exhibit enhanced stability and are useful for enhancing the growth of mammals and for increasing milk production in...

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Bibliographische Detailangaben
Hauptverfasser:	VIOLAND BERNARD NORMAN, SCHLITTLER MICHAEL ROBERT, KRIVI GWEN GRABOWSKI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FODDER FOODS OR FOODSTUFFS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention discloses variant somatotropins in which the asparagine located between positions 95-101 of a mammalian somatotropin are replaced by glutamine. Such somatotropins exhibit enhanced stability and are useful for enhancing the growth of mammals and for increasing milk production in a female mammal. Also disclosed is a DNA sequence coding for a mammalian somatotropin in which the codon for asparagine located between positions 95-101 of somatotropin is replaced by a codon for glutamine.