(2S)-(5-AMINO-1,2-DIHYDRO-2-METHYL-3-PHENYLPYRIDO[3,4-B] PYRAZIN-7-YL) CARBAMIC ACID, ETHYL ESTER

(2S)-(5-AMINO-1,2-DIHYDRO-2-METHYL-3-PHENYLPYRIDO[3,4-B] PYRAZIN-7-YL) CARBAMIC ACID, ETHYL ESTER

The (2S)-(-)isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido¢3,4-b!pyrazin-7-yl)carbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(~)-racemic mixture in inhibiting mitotic cell division of L1210 leukemia cells. The compound, pharmaceutical com...

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Bibliographische Detailangaben
1. Verfasser: TEMPLE, CARROLL G., JR
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The (2S)-(-)isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido¢3,4-b!pyrazin-7-yl)carbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(~)-racemic mixture in inhibiting mitotic cell division of L1210 leukemia cells. The compound, pharmaceutical compositions containing the compound, and a method of ameliorating cancer diseases in mammals are disclosed.