1-(3'-SUBSTITUED-2', 3'-DIDEOXY-D-RIBOFURANOSYL) THYMINE AND URACIL

A compound of the formula wherein the radicals A, X, R1, R2, and R3 are defined as follows: A : (a) or (b) X : (a) O (b) S (c) CH2 R1: H; alkyl containing 1-3 carbon atoms; -CH=CH2; -CH=CH-CH3; -CH2-CH=CH2; ; -C?CH R2: H; or R2 constitutes together with R3 a carbon - carbon bond R3: H; F; Cl; Br; I;...

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Bibliographische Detailangaben
Hauptverfasser:	JOHANSSON, KARL N. G, BERG, BO F, STENING, GOERAN B, DATEMAN, ROELF, LINDBORG, BJOERN G, KOVACS, ZSUZSANNA M. I
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	A compound of the formula wherein the radicals A, X, R1, R2, and R3 are defined as follows: A : (a) or (b) X : (a) O (b) S (c) CH2 R1: H; alkyl containing 1-3 carbon atoms; -CH=CH2; -CH=CH-CH3; -CH2-CH=CH2; ; -C?CH R2: H; or R2 constitutes together with R3 a carbon - carbon bond R3: H; F; Cl; Br; I; N3; CN; C?CH; OH; OCH3; CH2OH; and when R3 is F; Cl, Br; I; N3 ; CN; C?CH; OH; OCH3 or CH2OH it may have either the cis-configuration or trans-configuration relative to the hydroxymetyl function at position 4', or R3 constitutes together with R2 a carbon carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV virus infections.