MIXED CRYSTALS OF INSULIN AND INSULIN DERIVATIVES, A PROCESS FOR THE PREPARATION OF THESE MIXED CRYSTALS, PHARMACEUTICAL AGENTS CONTAINING THESE MIXED CRYSTALS, AND THE USE THEREOF FOR THE TREATMENT OF DIABETES MELLITUS

MIXED CRYSTALS OF INSULIN AND INSULIN DERIVATIVES, A PROCESS FOR THE PREPARATION OF THESE MIXED CRYSTALS, PHARMACEUTICAL AGENTS CONTAINING THESE MIXED CRYSTALS, AND THE USE THEREOF FOR THE TREATMENT OF DIABETES MELLITUS

Mixed crystals composed of A. unmodified insulin, des-Phe-B1 insulin, des-Thr-B30 (human) or des-Ala-B30 (pork, beef) insulin and B. at least one insulin having a basic modification at the C-terminal end of the B chain, preferably composed of human insulin (A) and Arg-B31 human insulin and/or Arg2-(...

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Bibliographische Detailangaben
Hauptverfasser: DOERSCHUG, MICHAEL, OBERMEIER, RAINER
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Mixed crystals composed of A. unmodified insulin, des-Phe-B1 insulin, des-Thr-B30 (human) or des-Ala-B30 (pork, beef) insulin and B. at least one insulin having a basic modification at the C-terminal end of the B chain, preferably composed of human insulin (A) and Arg-B31 human insulin and/or Arg2-(B31-32) human insulin (B) are obtained by crystallization from aqueous solution within a narrow pH range (from about 5.5 to about 6.9). The mixed crystals show a specific moderately prolonged profile and are suitable for the treatment of diabetes mellitus.