ANTIPARASITIC AGENTS

"Antiparasitic Avermectin Derivatives" Compounds of the formula: (I) wherein the broken line at the 22-23 position represents an optional double bond and wherein either R1 is H or OH and the double bond is absent, or, the double bond is present and R1 is absent; R2 is =CH2 or a group of th...

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Bibliographische Detailangaben
Hauptverfasser:	BANKS, BERNARD J, WITTY, MICHAEL J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY DERIVATIVES THEREOF FISHING FODDER FOODS OR FOODSTUFFS FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS THEIR TREATMENT, NOT COVERED BY OTHER CLASSES TRAPPING
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Beschreibung
Zusammenfassung:	"Antiparasitic Avermectin Derivatives" Compounds of the formula: (I) wherein the broken line at the 22-23 position represents an optional double bond and wherein either R1 is H or OH and the double bond is absent, or, the double bond is present and R1 is absent; R2 is =CH2 or a group of the formula -(X)-C(R5)=CHR6; R3 is H or CH3: R5 and R6 are both H; R5 is H and R6 is C1-C3 alkyl; or one of R5 and R6 is H and the other is phenyl, heteroaryl, C2-C6 alkoxycarbonyl or substituted phenyl or heteroaryl wherein said substituent is fluorine, chlorine, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, hydroxy(C1-C4)alkyl, cyano, aminosulphonyl, C2-C6 alkanoyl, C2-C6 alkoxycarbonyl, nitro, trifluoromethyl, trifluoromethoxy, amino or mono or di-C1-C4 alkylamino; and X is a direct bond or is an alkylene group having from 2 to 6 carbon atoms which may be straight or branched-chain; with the proviso that R5 and R6 are not both hydrogen when X is -CH(CH3)CH2-, are broad spectrum antiparasitic agents having utility as anthelmintics, ectoparasiticides, insecticides, acaricides and animal growth promotants.