METHOD OF THE VIRUS-INACTIVATING HEAT TREATMENT OF _-GLOBULIN AND HEAT-TREATED AQUEOUS SOLUTION CONTAINING THE SAME

A gamma-globulin aqueous solution can be subjected to sterile heat-treatment without loosing its activity when the treatment is conducted in the presence of at least one stabilizer of monosaccharide, disaccharide or sugaralcohol added to the solution. The stabilizer effects to decrease the harmful p...

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Hauptverfasser: URIYU, KATUHIRO, UEMURA, YAHIRO, HIRAO, YUTAKA
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:A gamma-globulin aqueous solution can be subjected to sterile heat-treatment without loosing its activity when the treatment is conducted in the presence of at least one stabilizer of monosaccharide, disaccharide or sugaralcohol added to the solution. The stabilizer effects to decrease the harmful polymer or anticomplement activity of the gamma-globulin before the treatment but to maintain the titer of a wide variety of antibodies to various viruses and bacteria, while the infectivity of viruses possibly contained is completely removed. Another stabilizer of a neutral amino and, a neutral inorganic salt, an organic carboxylic acid salt or a surface active agent assists the stabilizer when used together.