PHOSPHATE ESTER DERIVATIVES, AND THEIR USE AS ANTI-CANCER AGENTS

Compounds of formula (I): (I) (wherein: m is 1-3; A and B are oxygen or sulfur; and one of R1 and R2 is C10-C22 alkyl and the other is a group of formula (II): (II) where: n is 2 or 3; and -NR3R4R5 is an amino group! and salts thereof are effective anti-cancer agents and may be prepared by condensat...

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Bibliographische Detailangaben
Hauptverfasser:	MIYAZAKI, HIDEKI, SHIMIZU, FUSAAKI, NAKAMURA, NORIO, SASAGAWA, KAZUHIKO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of formula (I): (I) (wherein: m is 1-3; A and B are oxygen or sulfur; and one of R1 and R2 is C10-C22 alkyl and the other is a group of formula (II): (II) where: n is 2 or 3; and -NR3R4R5 is an amino group! and salts thereof are effective anti-cancer agents and may be prepared by condensation of an appropriate .omega.-haloalkyl phosphate or cyclic phosphate with an amine of formula NR3R4R5.