METHOD OF CHLORINATION
P.C. 7187 NOVEL METHOD OF CHLORINATION A novel process for chlorinating 2-methoxy-nicotinic acid at the 5-position of the molecule is disclosed. The process involves the use of an alkali metal hypochlorite as the chlorinating agent in a homogeneous aqueous solvent system. The compound so produced, 5...
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Zusammenfassung: | P.C. 7187 NOVEL METHOD OF CHLORINATION A novel process for chlorinating 2-methoxy-nicotinic acid at the 5-position of the molecule is disclosed. The process involves the use of an alkali metal hypochlorite as the chlorinating agent in a homogeneous aqueous solvent system. The compound so produced, 5-chloro-2-methoxynicotinic acid, is known to be useful as an intermediate leading to various oral hypoglycemic agents of the benzenesulfonylurea class. |
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