OCTAHYDROTHIAZOLO[4,5-Q]QUINOLINES

OCTAHYDROTHIAZOLO[4,5-Q]QUINOLINES

Trans-(?)-2,5-optionally substitutedoctahydrothiazolo ¢4,5-g! quinolines, or their enantiomers, of the formula I wherein R is H, benzyl, methyl, ethyl, n-propyl or allyl; R1 is H, OH, halogen,methyl, NH2, NHC1-3 alkyl, N(C1-3 alkyl)2, 1-pyrrolidinyl, NHCOC1-3 alkyl, or NHC1-2 alkylphenyl; or their p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KORNFELD, EDMUND C, TITUS, ROBERT D
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Trans-(?)-2,5-optionally substitutedoctahydrothiazolo ¢4,5-g! quinolines, or their enantiomers, of the formula I wherein R is H, benzyl, methyl, ethyl, n-propyl or allyl; R1 is H, OH, halogen,methyl, NH2, NHC1-3 alkyl, N(C1-3 alkyl)2, 1-pyrrolidinyl, NHCOC1-3 alkyl, or NHC1-2 alkylphenyl; or their pharmaceutically acceptable acid addition or quaternary salts thereof, are provided by the present invention. As D-2 dopamine agonists, the compounds of this invention are useful in treating Parkinson's Syndrome, in treating sexual dysfunction, as antidepressants and anti-anxiety agents in lowering blood pressure in hypertensive animals, and in inhibiting prolactin secretion.