PROCESS FOR PRODUCING 3-IMIDAZOLYLMETHYLTETRAHYDROCARBAZOLONES

PROCESS FOR PRODUCING 3-IMIDAZOLYLMETHYLTETRAHYDROCARBAZOLONES

The invention relates to a process for the preparation of a compound of general formula (I) (I) wherein R1 represents a hydrogen atom or a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-(C1-4)alkyl, C3-6 alkenyl, C3-10 alkynyl, phenyl or phenyl-(C1-3)alkyl group, and one of the groups represented by...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: COATES, IAN H, HUMBER, DAVID C, EWAN, GEORGE B, ELDRED, COLIN D, OXFORD, ALEXANDER W, BELL, JAMES A
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to a process for the preparation of a compound of general formula (I) (I) wherein R1 represents a hydrogen atom or a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-(C1-4)alkyl, C3-6 alkenyl, C3-10 alkynyl, phenyl or phenyl-(C1-3)alkyl group, and one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-(C1-3)alkyl group and each of the other two groups, which may be the same or different, represent a hydrogen atom or a C1-6 alkyl group; or a salt or protected derivative thereof, by cyclisation of a compound of general formula (II) (II) wherein R1, R2, R3 and R4 are as defined above, or a salt or a protected derivative thereof. The compounds of formula (I) are potent and selective antagonists at "neuronal" 5-hydroxytryptamine receptors.