BICYCLO-SUBSTITUTED PHENYLACETONITRILE DERIVATIVES

BICYCLO-SUBSTITUTED PHENYLACETONITRILE DERIVATIVES

ABSTRACT OF THE INVENTION The invention relates to compounds of the formula: and the pharmaceutically acceptable salts and hydrates thereof wherein R1 and R2 are the same or different and each is selected from hydrogen,halo, C1-C4 alkyl, C1-C4 alkoxy or tri-fluoromethyl; R3 is selected from straight...

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Bibliographische Detailangaben
1. Verfasser: LIANG, CHI-DEAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:ABSTRACT OF THE INVENTION The invention relates to compounds of the formula: and the pharmaceutically acceptable salts and hydrates thereof wherein R1 and R2 are the same or different and each is selected from hydrogen,halo, C1-C4 alkyl, C1-C4 alkoxy or tri-fluoromethyl; R3 is selected from straight or branched chain (a) alkyl of from about 1 to 15 carbon atoms or (b) alkenyl of from about 2 to 15 carbon atoms; R4 is selected from hydrogen or C1-C4 alkyl; R5 is a bicyclic group selected from or wherein R6 and R7 are the same as defined above for R1 and R2; and n is an integer from 2 to 4, inclusive; which are useful as cardiovascular agents.