DERIVATIVES OF IMIDAZOLE, THEIR PREPARATION AND UTILISATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES

ABSTRACT Derivatives of imidazole corresponding to formula I wherein X1, X2, Y1 and Y2, whether or not identical, can have different significancies, R1 is hydrogen, a methyl or phenyl group, R2 and R3, whether or not identical, represent hydrogen, a hydroxyl, alkyl or alkoxy group, it being possible...

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Hauptverfasser: CORDI, ALEXIS A, CALDERON, PIEDAD, ROBA, JOSEPH L, GORISSEN, HUGO J, LAMBELIN, GEORGES E, SNYERS, MICHEL P, VAN DORSSER, WILLIAM R, GILLET, CLAUDE L
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Sprache:eng ; fre
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Zusammenfassung:ABSTRACT Derivatives of imidazole corresponding to formula I wherein X1, X2, Y1 and Y2, whether or not identical, can have different significancies, R1 is hydrogen, a methyl or phenyl group, R2 and R3, whether or not identical, represent hydrogen, a hydroxyl, alkyl or alkoxy group, it being possible for R1 and R2 together to represent a carbon-carbon bond, R4 and R5, whether or not iden-tical, being hydrogen or alkyl, and the tautomers and salts of these compounds, also the pharmaceutical com-positions containing them. The compounds are endowed with .alpha.2-blocking and/or anti-convulsive activities and are utilisable as therapeutic agents for man.