RHIZOXIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE

RHIZOXIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL USE

Acylated derivatives of rhizoxin and of the formula wherein: (I) R represents an alkyl group having at least 2 carbon atoms; and A represents an extra carbon-carbon bond or an oxygen atom and pharmaceutically acceptable salts and ring-closed lactones thereof have excellent anti-tumour activity.

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Bibliographische Detailangaben
Hauptverfasser: SHIMIZU, FUSAAKI, IWASAKI, SHIGEO, OKUDA, SHIGENOBU, ARAKAWA, MASAO, NAMIKOSHI, MICHIO
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Acylated derivatives of rhizoxin and of the formula wherein: (I) R represents an alkyl group having at least 2 carbon atoms; and A represents an extra carbon-carbon bond or an oxygen atom and pharmaceutically acceptable salts and ring-closed lactones thereof have excellent anti-tumour activity.