TUMOR RETARDING (1-BENZYL-ETHYLENEDIAMINE)-PLATIN(II)- COMPLEXES
There are described (1-benzyl- ethylenediamine)-platin(II)-complexes of the general formula: wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1-C6-alkyl group, C1 henzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl...
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creator | SCHONENBERGER, HELMUT SCHMIDT, MANFRED BRUNNER, HENRI UNGER, GERFRIED HOLZINGER, ULRICH ENGEL, JURGEN |
description | There are described (1-benzyl- ethylenediamine)-platin(II)-complexes of the general formula: wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1-C6-alkyl group, C1 henzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl radical, or a phenyl radical substituted by the radicals R5, R6, and R7 which are the same or different and are hydrogen, halogen, trihalomethyl, C1-C6-alkyl, hydroxy, C1-C6-alkoxy, phenoxy, benzyloxy, C1-C6-alkanoyloxy, benzoyloxy, C1-C6- alkanesulfonyloxy, carboxy, C1-C6-carbalkoxy, cyano, aminocarboxyl , aminocarbonyl, which contains one or two C1-C6-alkyl radicals, C1-C6-alkylcarbonyl, nitro, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkyl)3N+, C1-C6-alkanoylamino, C1-C"-alkyl- C1-C6-alkanoylamino, C1-C6-alkanesulfonylamino, C1C6-alkyl-C1-C6-alkanesulfonylamino, aminosulfonyl, aminosulfonyl which contains one or two C1-C6-alkyl radicals, C1-C6-alkoxysulfonyl (-SO2-0-C1-C6-alkyl), sulfo (-SO3H) or C1-C6-alkanesulfonyl and two of these groups can be the methylenedioxy group and X is the equivalent of a physiologically compatible anion, as well as optionally their salts with physiologically compatible cations and anions and process of their production. The complexes have good antitumor activity with good compatiblity. |
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The complexes have good antitumor activity with good compatiblity.</description><edition>6</edition><language>eng ; fre</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1990</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900424&DB=EPODOC&CC=CA&NR=1268182A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900424&DB=EPODOC&CC=CA&NR=1268182A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHONENBERGER, HELMUT</creatorcontrib><creatorcontrib>SCHMIDT, MANFRED</creatorcontrib><creatorcontrib>BRUNNER, HENRI</creatorcontrib><creatorcontrib>UNGER, GERFRIED</creatorcontrib><creatorcontrib>HOLZINGER, ULRICH</creatorcontrib><creatorcontrib>ENGEL, JURGEN</creatorcontrib><title>TUMOR RETARDING (1-BENZYL-ETHYLENEDIAMINE)-PLATIN(II)- COMPLEXES</title><description>There are described (1-benzyl- ethylenediamine)-platin(II)-complexes of the general formula: wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1-C6-alkyl group, C1 henzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl radical, or a phenyl radical substituted by the radicals R5, R6, and R7 which are the same or different and are hydrogen, halogen, trihalomethyl, C1-C6-alkyl, hydroxy, C1-C6-alkoxy, phenoxy, benzyloxy, C1-C6-alkanoyloxy, benzoyloxy, C1-C6- alkanesulfonyloxy, carboxy, C1-C6-carbalkoxy, cyano, aminocarboxyl , aminocarbonyl, which contains one or two C1-C6-alkyl radicals, C1-C6-alkylcarbonyl, nitro, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkyl)3N+, C1-C6-alkanoylamino, C1-C"-alkyl- C1-C6-alkanoylamino, C1-C6-alkanesulfonylamino, C1C6-alkyl-C1-C6-alkanesulfonylamino, aminosulfonyl, aminosulfonyl which contains one or two C1-C6-alkyl radicals, C1-C6-alkoxysulfonyl (-SO2-0-C1-C6-alkyl), sulfo (-SO3H) or C1-C6-alkanesulfonyl and two of these groups can be the methylenedioxy group and X is the equivalent of a physiologically compatible anion, as well as optionally their salts with physiologically compatible cations and anions and process of their production. 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The complexes have good antitumor activity with good compatiblity.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | TUMOR RETARDING (1-BENZYL-ETHYLENEDIAMINE)-PLATIN(II)- COMPLEXES |
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