TUMOR RETARDING (1-BENZYL-ETHYLENEDIAMINE)-PLATIN(II)- COMPLEXES

There are described (1-benzyl- ethylenediamine)-platin(II)-complexes of the general formula: wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1-C6-alkyl group, C1 henzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl...

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Hauptverfasser: SCHONENBERGER, HELMUT, SCHMIDT, MANFRED, BRUNNER, HENRI, UNGER, GERFRIED, HOLZINGER, ULRICH, ENGEL, JURGEN
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SCHMIDT, MANFRED
BRUNNER, HENRI
UNGER, GERFRIED
HOLZINGER, ULRICH
ENGEL, JURGEN
description There are described (1-benzyl- ethylenediamine)-platin(II)-complexes of the general formula: wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1-C6-alkyl group, C1 henzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl radical, or a phenyl radical substituted by the radicals R5, R6, and R7 which are the same or different and are hydrogen, halogen, trihalomethyl, C1-C6-alkyl, hydroxy, C1-C6-alkoxy, phenoxy, benzyloxy, C1-C6-alkanoyloxy, benzoyloxy, C1-C6- alkanesulfonyloxy, carboxy, C1-C6-carbalkoxy, cyano, aminocarboxyl , aminocarbonyl, which contains one or two C1-C6-alkyl radicals, C1-C6-alkylcarbonyl, nitro, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkyl)3N+, C1-C6-alkanoylamino, C1-C"-alkyl- C1-C6-alkanoylamino, C1-C6-alkanesulfonylamino, C1C6-alkyl-C1-C6-alkanesulfonylamino, aminosulfonyl, aminosulfonyl which contains one or two C1-C6-alkyl radicals, C1-C6-alkoxysulfonyl (-SO2-0-C1-C6-alkyl), sulfo (-SO3H) or C1-C6-alkanesulfonyl and two of these groups can be the methylenedioxy group and X is the equivalent of a physiologically compatible anion, as well as optionally their salts with physiologically compatible cations and anions and process of their production. The complexes have good antitumor activity with good compatiblity.
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The complexes have good antitumor activity with good compatiblity.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title TUMOR RETARDING (1-BENZYL-ETHYLENEDIAMINE)-PLATIN(II)- COMPLEXES
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