TUMOR RETARDING (1-BENZYL-ETHYLENEDIAMINE)-PLATIN(II)- COMPLEXES

There are described (1-benzyl- ethylenediamine)-platin(II)-complexes of the general formula: wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1-C6-alkyl group, C1 henzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SCHONENBERGER, HELMUT, SCHMIDT, MANFRED, BRUNNER, HENRI, UNGER, GERFRIED, HOLZINGER, ULRICH, ENGEL, JURGEN
Format: Patent
Sprache:eng ; fre
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:There are described (1-benzyl- ethylenediamine)-platin(II)-complexes of the general formula: wherein the radicals R1, R2, R3, and R4 are the same or different and are hydrogen, a C1-C6-alkyl group, C1 henzyl group, or a phenylethyl group, and B is a thienyl radical, an indolyl radical, an imidazolyl radical, or a phenyl radical substituted by the radicals R5, R6, and R7 which are the same or different and are hydrogen, halogen, trihalomethyl, C1-C6-alkyl, hydroxy, C1-C6-alkoxy, phenoxy, benzyloxy, C1-C6-alkanoyloxy, benzoyloxy, C1-C6- alkanesulfonyloxy, carboxy, C1-C6-carbalkoxy, cyano, aminocarboxyl , aminocarbonyl, which contains one or two C1-C6-alkyl radicals, C1-C6-alkylcarbonyl, nitro, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-alkyl)3N+, C1-C6-alkanoylamino, C1-C"-alkyl- C1-C6-alkanoylamino, C1-C6-alkanesulfonylamino, C1C6-alkyl-C1-C6-alkanesulfonylamino, aminosulfonyl, aminosulfonyl which contains one or two C1-C6-alkyl radicals, C1-C6-alkoxysulfonyl (-SO2-0-C1-C6-alkyl), sulfo (-SO3H) or C1-C6-alkanesulfonyl and two of these groups can be the methylenedioxy group and X is the equivalent of a physiologically compatible anion, as well as optionally their salts with physiologically compatible cations and anions and process of their production. The complexes have good antitumor activity with good compatiblity.