POLYPEPTIDE MARKER FOR ALZHEIMER'S DISEASE AND ITS USE FOR DIAGNOSIS

A POLYPEPTIDE MARKER FOR ALZHEIMER'S DISEASE AND ITS USE FOR DIAGNOSIS A novel polypeptide, Alzheimer's Amyloid Polypeptide (AAP), is provided in substantially purified form which 18 isolated from amyloid deposits in patients with Alzheimer's Disease. The polypeptide has the following...

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Hauptverfasser:	WONG, CAINE W, GLENNER, GEORGE G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A POLYPEPTIDE MARKER FOR ALZHEIMER'S DISEASE AND ITS USE FOR DIAGNOSIS A novel polypeptide, Alzheimer's Amyloid Polypeptide (AAP), is provided in substantially purified form which 18 isolated from amyloid deposits in patients with Alzheimer's Disease. The polypeptide has the following amino acid sequence: H2N-ASP-AIA-GLU-PHE-ARG-HIS-ASP- SER-GLY-TYR-GLN-VAL-HIS-HIS-GLN- LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP- VAL-GLY-SER-ASN-LYS-COOH. The polypeptide, or fragmentS thereof, may be used to produce antibodies useful in a diagnostic test for Alzheimer's Disease. Nucleotide probes corresponding to portions of the polypeptide are also useful for diagnostic purposes.