METHOD FOR PRODUCING 2-(SUBSTITUTED ARYL)PROPIONALDEHYDE

METHOD FOR PRODUCING 2-(SUBSTITUTED ARYL)PROPIONALDEHYDE

of the disclosure: A 2-(substituted aryl)propionaldehyde of the formula, (wherein Ar denotes is produced in high yield by reacting a methyl (substituted aryl) ketone of the formula, Ar-?-CH3 with phenyldimethylsulfonium methylsulfate of the formula, in the presence of alkali metal hydroxide to obtai...

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Bibliographische Detailangaben
Hauptverfasser: MAEDA, SADAYUKI, SHINOO, YASUTAKA, TAKENAKA, SHINJI, ARASHIDA, SUSUMU, SHIMIZU, IWAO
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:of the disclosure: A 2-(substituted aryl)propionaldehyde of the formula, (wherein Ar denotes is produced in high yield by reacting a methyl (substituted aryl) ketone of the formula, Ar-?-CH3 with phenyldimethylsulfonium methylsulfate of the formula, in the presence of alkali metal hydroxide to obtain a reaction mixture containing 2-(substituted aryl)1,2-epoxy-propane of the formula, and thioanisole, and subjecting the reaction mixture to contact with anhydrous MgCl2. The propionaldehyde compound is also produced in high yield by contacting the epoxypropane compound with anhydrous MgCl2 in the presence of a soft nucleophile such as a sulfide, a thiol and a phosphine.