N-SUBSTITUTED 2-CHLORO-7-FLUORO-10-PIPERAZINO-10,11- DIHYDRODIBENZO (B,F)THIEPINS, THEIR ACID ADDITION SALTS AND PROCESSES FOR THE PREPARATION THEREOF

N-SUBSTITUTED 2-CHLORO-7-FLUORO-10-PIPERAZINO-10,11- DIHYDRODIBENZO (B,F)THIEPINS, THEIR ACID ADDITION SALTS AND PROCESSES FOR THE PREPARATION THEREOF

The invention relates to N-substituted 2-chloro-7-fluoro 10-piperazino-10,11-dihydrodibenzo/b,f/thiepins of the general formula I ( I ) in which R represents an aminocarbonyl, amino-oximinomethyl, 1,3-dioxolan-2-yl or 1,3 dioxan-2-yl group, and their pharmaceutically acceptable addition salts with o...

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Bibliographische Detailangaben
Hauptverfasser: JILEK, JIRI, CERVENA, IRENA, VALCHAR, MARTIN, PROTIVA, MIROSLAV, POMYKACEK, JOSEF, DLABAC, ANTONIN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to N-substituted 2-chloro-7-fluoro 10-piperazino-10,11-dihydrodibenzo/b,f/thiepins of the general formula I ( I ) in which R represents an aminocarbonyl, amino-oximinomethyl, 1,3-dioxolan-2-yl or 1,3 dioxan-2-yl group, and their pharmaceutically acceptable addition salts with organic and inorganic acids. These compounds are highly potent antidopaminergic, non-cataleptic neuroleptics of presumed use in the treatment of schizophrenia; according to recent pharmacological assay results, the subject compounds are expected to be substantially free of the usual undesired extrapyramidal side effects. The invention also relates to a process for the preparation of these compounds.