AMINOGUANIDINE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF

The invention relates to new aminoguanidine derivatives of the general formula (I), wherein R1, R2 and R3 each represent hydrogen or halogen atom, C1-4 alkyl, nitro, trifluoromethyl or C1-4 alkoxy group, R4 and R5 represent a C1-4 alkyl group, furthermore NR4R5 may form a 5 to 7 membered saturated h...

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Bibliographische Detailangaben
Hauptverfasser: JASZLITS, LASZLO, MAROSFALVI, JENOE, VARRO, ANDRAS, ERCZI, ISTVAN, ELEKES, ISTVAN, SZATMARY, LASZLO, KUHAR, MARIA NEE KUERTHY, RABLOCZKY, GYOERGY
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The invention relates to new aminoguanidine derivatives of the general formula (I), wherein R1, R2 and R3 each represent hydrogen or halogen atom, C1-4 alkyl, nitro, trifluoromethyl or C1-4 alkoxy group, R4 and R5 represent a C1-4 alkyl group, furthermore NR4R5 may form a 5 to 7 membered saturated heterocyclic group containing either one or two nitrogen atoms or a nitrogen and an oxygen atom and being optionally substituted by one or two methyl, hydroxymethyl or hydroxyethyl groups, R6 and R7 each represent a hydrogen atom, normal or branched C1-4 alkyl or C2-4 alkenyl group, and to their pharmaceutically acceptable acid addition salts as well as to a process for the preparation thereof. The new compounds of the invention possess valuable antiarrhythmic activity and are devoid of the undesired circulatory side effects of the known antiarrhythmic compounds.