PYRIMIDO(4,5-G)QUINOLINES AND INTERMEDIATES

PYRIMIDO(4,5-G)QUINOLINES AND INTERMEDIATES

Trans-(+)-2-Amino (or substituted amino)-4- (permissibly-substituted)-6-C1-C3 alkyl (or allyl)-5,5a,-6,7,8,9,9a,10-octahydropyrimido¢4,5-g!quinolines, the corresponding trans-(-) and trans-(+)-stereoisomers and salts thereof, useful in treating Parkinson's Syndrome, sexual dysfunction, depressi...

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Bibliographische Detailangaben
Hauptverfasser: KORNFELD, EDMUND C, WONG, DAVID T, NICHOLS, CYNTHIA L, FOREMAN, MARK M, HUSER, DIANE L, BOOHER, RICHARD N, SCHAUS, JOHN M
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Trans-(+)-2-Amino (or substituted amino)-4- (permissibly-substituted)-6-C1-C3 alkyl (or allyl)-5,5a,-6,7,8,9,9a,10-octahydropyrimido¢4,5-g!quinolines, the corresponding trans-(-) and trans-(+)-stereoisomers and salts thereof, useful in treating Parkinson's Syndrome, sexual dysfunction, depression, hypertension, and prolactin related diseases, and intermediates useful for the synthesis thereof, are disclosed. The products are prepared by condensing an appropriate ketone with the appropriately substltuted guanidine.