PROCESS OF PRODUCING ALKYLANGELICINS FREE FROM PSORALENS AND ALKYLANGELICINS OBTAINED THEREFROM

PROCESS OF PRODUCING ALKYLANGELICINS FREE FROM PSORALENS AND ALKYLANGELICINS OBTAINED THEREFROM

The alkylangelicins according to the invention are obtained starting from an umbelliferone, in which the 6-position is already substituted by an alkyl group; in such a way the 7-allyloxy or 7-acyloxy umbelliferone intermediates can form by transposition of the allyl or acyl group only the 8-allyl an...

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Bibliographische Detailangaben
Hauptverfasser: GUIOTTO, ADRIANO, CRISTOFOLINI, MARIO, PASTORINI, GIOVANNI, VEDALDI, DANIELA, BACCICHETTI, FRANCAROSA, RODIGHIERO, GIOVANNI, BORDIN, FRANCO, BRAGADIN MONTI, CARLO, CARLASSARE, FRANCESCO, DALL'ACQUA, FRANCESCO, RODIGHIERO, PAOLO, RECCHIA, GIOVANNI
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The alkylangelicins according to the invention are obtained starting from an umbelliferone, in which the 6-position is already substituted by an alkyl group; in such a way the 7-allyloxy or 7-acyloxy umbelliferone intermediates can form by transposition of the allyl or acyl group only the 8-allyl and 8-acyl derivatives, and therefore the presence, even in traces, of psoralens is absolutely excluded in the subsequent synthetic steps. The 6-alkylangelicins thus obtained are particularly usable for the photochemotherapy of psoriasys and of other skin diseases characterized by cellular hyperproliferation, as well as for the photochemotherapy of vitiligo and of alopecia aerata.