METHOD FOR THE PREPARATION OF 1,8-DIHYDROXY-10-ACYL-9- ANTHRONES, ESPECIALLY FOR USE IN THE TREATMENT OF PSORIASIS

The invention relates to a method for the preparation of 1,8-dihydroxy-10-acyl-9-anthrone, especially for use in the treatment of psoriasis, having the formula < IMG > where R is an alkyl group having 2-4 carbon atoms, by using as the initial material 1,8-dihydroxy-9-anthrone and an acid chlor...

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Bibliographische Detailangaben
Hauptverfasser:	PIPPURI, AINO K, HONKANEN, ERKKI J, KAIRISALO, PEKKA J
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The invention relates to a method for the preparation of 1,8-dihydroxy-10-acyl-9-anthrone, especially for use in the treatment of psoriasis, having the formula < IMG > where R is an alkyl group having 2-4 carbon atoms, by using as the initial material 1,8-dihydroxy-9-anthrone and an acid chloride having the formula RCOC1, where R represents the same as above. In accordance with the invention, harmful benzene can be replaced with, for example toluene; this replacing is possible because pyridine is replaced with 2,6-dimethyl pyridine.