PROCESS FOR THE PREPARATION OF HYDROCHLORIDES

PROCESS FOR THE PREPARATION OF HYDROCHLORIDES

PROCESS FOR THE PREPARATION OF HYDROCHLIRIDES A b s t r a c t The invention relates to a process for the preparation of hydrochlorides, i.e. of acid addition salts formed with hydrochloric acid, particularly of compounds containing a protonatable nitrogen atom According to the process of the inventi...

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Bibliographische Detailangaben
Hauptverfasser: KUN, LAJOS, CSEKE, LASZLO, BALINT, JANOS, SZARVAS, MIKLOS, HORVATH, EVA (NEE FEHER), FABIAN, FERENC
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
DERIVATIVES THEREOF
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
STEROIDS
SUGARS
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Beschreibung
Zusammenfassung:PROCESS FOR THE PREPARATION OF HYDROCHLIRIDES A b s t r a c t The invention relates to a process for the preparation of hydrochlorides, i.e. of acid addition salts formed with hydrochloric acid, particularly of compounds containing a protonatable nitrogen atom According to the process of the invention a compound useful to form a hydrochloride and being suitably in the form of a derivative containing protonatable nitrogen atom or in the form of a salt is reacted with a sulphonyl compound of the formula Q - SO2 - Cl, wherein Q stands for a hydroxyl, C1-4 alkyl or an aryl group, the latter being optionally substituted by a C1-4 alkyl group, in a solvent, in the presence of an alcohol, whereupon the hydrochloride obtained is recovered in a known manner.