SUBSTITUTED ACYL DERIVATIVES OF OCTAHYDRO-1H-INDOLE-2- CARBOXYLIC ACIDS

. An octahydro-1-(.omega.-mercaptoalkanoyl)-1H-indole-2-carboxylic acid and derivatives thereof, and an octahydrolH-indole-2-carboxylic acid and derivatives thereof having the general formula: < IMG > (i) and < IMG > (xiv) wherein R and R4 are hydrogen, straight and branched chain alkyl of from 1 to 4 carbon atoms, R1 is hydrogen, benzyl, straight and branched chain alkyl of from 1 to 4 carbon atoms, R2 is hydrogen and R3-CO-, wherein R3 is phenyl, straight and branched alkyl of from 1 to 4 carbon atoms, R5 is hydrogen, benzyl, straight and branched chain alkyl of from 1 to 4 carbon atoms, R6 is hydrogen, straight and branched chain alkyl of from 1 to 4 carbon atoms, Ar is phenyl, mono- and di-substituted phenyl, wherein the substituents are fluorine, chlorine, bromine, hydroxy, amino, straight and branched chain alkyl and alkoxy of from 1 to 4 carbon atoms, m is 0, 1, 2 or 3, and n is 0 or 1, and pharmaceutically acceptable salts thereof; and methods for their preparation. The compounds of the invention are useful as antihypertensive agents.