PROCESS FOR THE PREPARATION OF 2-[[[5- (DIMETHYLAMINO)METHYL-2-FURANYLMETHYLTHIO FURANYL]METHYL]THIO]ETHANEAMINE ETHANEAMINE

PROCESS FOR THE PREPARATION OF 2-[[[5- (DIMETHYLAMINO)METHYL-2-FURANYLMETHYLTHIO FURANYL]METHYL]THIO]ETHANEAMINE ETHANEAMINE

A new process for the preparation of 2-¢¢¢5-(dimethyl-aminol-methyl-2-furany! methy! thio!ethaneamine of the formula is described, wherein 2-¢¢¢5-(dimethylamino)methyl-2-furany! methyl! thio!ethanol of the formula is halogenated to the corresponding halogenide of the formula wherein Hal is chlorine...

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Bibliographische Detailangaben
Hauptverfasser: LAH, JOLANDA, HRIBAR-KIKELJ, ALENKA, ZMITEK, JANKO
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A new process for the preparation of 2-¢¢¢5-(dimethyl-aminol-methyl-2-furany! methy! thio!ethaneamine of the formula is described, wherein 2-¢¢¢5-(dimethylamino)methyl-2-furany! methyl! thio!ethanol of the formula is halogenated to the corresponding halogenide of the formula wherein Hal is chlorine or bromine, and the resulting compound is aminated with ammonia to yield the desired compound. The desired compound represents a valuable intermediate for the preparation of the therapeutically important compound ranitidine, which is used for the treatment of ulcer diseases.