PROCESS FOR PREPARING N-PYRROLYL-PYRIDAZINEAMINE DERIVATIVES

PROCESS FOR PREPARING N-PYRROLYL-PYRIDAZINEAMINE DERIVATIVES

The present invention refers to a new process for preparing N-2,3,4,5-substituted-1H-pyrrol-1-yl)-6-substituted amino-3-pyridazineamine, known as antihypertensive agents. The process is characterized in that a suitable 3,6-diha-logenopyridazine is reacted with hydrazine hydrate or other hydrazine de...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: BELLASIO, ELVIO
Format: Patent
Sprache:eng ; fre
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention refers to a new process for preparing N-2,3,4,5-substituted-1H-pyrrol-1-yl)-6-substituted amino-3-pyridazineamine, known as antihypertensive agents. The process is characterized in that a suitable 3,6-diha-logenopyridazine is reacted with hydrazine hydrate or other hydrazine derivatives of formula NH2 NHR, the obtained compound is reacted with a suitable dicarbonyl compound yielding first an alcandlone-bis- -¢6-halogen-3-pyridazinyl!hydrazone, and then a 6-halogen- -3-pyrrolylpyridazineamine derivative which is in turn reacted with an amine to yield the desired compounds.