2-(2-AMINOTHIAZOL-4-YL)-N-(IMIDAZOLIDIN-2-ON-1-YL)-2- IMINO-ACETYLAMINOCEPHALOSPORANIC ACIDS IN PURE SYN- FORM, A PROCESS FOR THEIR PRODUCTION AND SYN-ACID USED IN SUCH A PROCESS

2-(2-AMINOTHIAZOL-4-YL)-N-(IMIDAZOLIDIN-2-ON-1-YL)-2- IMINO-ACETYLAMINOCEPHALOSPORANIC ACIDS IN PURE SYN- FORM, A PROCESS FOR THEIR PRODUCTION AND SYN-ACID USED IN SUCH A PROCESS

A pure syn-form cephalosporin of the formula in which n is 2, 3 or 4, R1 represents a hydrogen atom, a pharmaceutically acceptable metal cation, an ammonium cation of a pharmaceutically acceptable nitrogen base, a radical of an ester of, if another part of the molecule contains a positive charge, a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KOENIG, HANS-BODO, METZGER, KARL G
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A pure syn-form cephalosporin of the formula in which n is 2, 3 or 4, R1 represents a hydrogen atom, a pharmaceutically acceptable metal cation, an ammonium cation of a pharmaceutically acceptable nitrogen base, a radical of an ester of, if another part of the molecule contains a positive charge, a negative charge, T denotes -CH3, -CH2-O-CO-CH3, ¢in which Z denotes O or S), -O-CO-NH2, or and Y denotes -S- or -?-, is produced by reacting aminothiazolylglyoxylic acid of the formula with the hydrazine compound of the formula to give a syn-acid of the formula and reacting the syn-acid with a halogenating agent, and then in the absence of a base with a 7-aminocephalosporanic acid derivative of the formula The pure syn-form of the cephalosporin is considerably more active as an antibiotic than the antii-form.