ALKYLATED PREGNANES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

ALKYLATED PREGNANES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: wherein R1 = alkyl (1-4 C); R2 = carboxyacyl (1-18 C); X = H, F or Cl; Y = O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MCGARRY, GEORGE, CAIRNS, JAMES, WOODS, GILBERT F, LOGAN, ROBERT T, ROY, ROBERT G
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Beschreibung
Zusammenfassung:The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: wherein R1 = alkyl (1-4 C); R2 = carboxyacyl (1-18 C); X = H, F or Cl; Y = O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same. The novel compounds possess strong anti-inflammatory propertles, when applied locally and cause little or no systemic, thymolytic, adrenolytic and salt-retaining effects.