DERIVATIVES OF PYRIDO[4,3-B] CARBAZOLES (ELLIPTICINES), SUBSTITUTED IN THE 1 POSITION BY A POLYAMINE CHAIN, PROCESS FOR PREPARING THEM, THEIR PHARMACEUTICAL COMPOSITONS AND THERAPEUTIC TREATMENTS THEREWITH

The novel derivatives correspond to the general formula: (I) in which R1 is a Y-(CH2)n -NR4R5 group, where Y represents a single bond or the group , R4 and R5, identical or different, are hydrogen or an alkyl radical, preferably a lower alkyl, or again form together a ring which can include heteroat...

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Hauptverfasser: MONTAGNIER, LUC, DUCROCQ, CLAIRE, CHERMANN, JEAN-CLAUDE, GRUEST, JACQUELINE, WENDLING, FRANCOISE, BISAGNI, EMILE, LIDEREAU, ROSETTE, TAMBOURIN, PIERRE, CIVIER, ALAIN, RIVALLE, CHRISTIAN
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Sprache:eng ; fre
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Zusammenfassung:The novel derivatives correspond to the general formula: (I) in which R1 is a Y-(CH2)n -NR4R5 group, where Y represents a single bond or the group , R4 and R5, identical or different, are hydrogen or an alkyl radical, preferably a lower alkyl, or again form together a ring which can include heteroatoms, in particular nitrogen atoms. n is a number ranging from 1 to 10, notably from 2 to 7, R2 is a hydrogen atom, a lower alkyl group or an aralkyl group in which the alkyl substituent is a lower alkyl group, and R3 is a hydrogen atom or a CH3 group. The compounds have antitumoral and antiviral properties useful for the treatment of cancers.